The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock
نویسندگان
چکیده
منابع مشابه
The yeast endosomal Na+/H+ exchanger, Nhx1, confers osmotolerance following acute hypertonic shock.
Osmotolerance in yeast is regulated by at least two distinct mechanisms. The acquired response occurs following long-term exposure to hypertonic medium and requires the induction of the HOG-MAP (high-osmolarity glycerol mitogen-activated protein) kinase cascade to increase levels of the osmolyte glycerol. The acute response occurs following sudden exposure to high osmotica and appears to be dep...
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The relationship between endosomal pH and function is well documented in viral entry, endosomal maturation, receptor recycling, and vesicle targeting within the endocytic pathway. However, specific molecular mechanisms that either sense or regulate luminal pH to mediate these processes have not been identified. Herein we describe the use of novel, compartment-specific pH indicators to demonstra...
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Nhx1, the endosomal Na/H exchanger of Saccharomyces cerevisiae represents the founding member of a newly emerging subfamily of intracellular Na/H exchangers. These proteins share significantly greater sequence homology to one another than to members of the mammalian Na/H exchanger (NHE) family encoding plasma membrane Na/H exchangers. Members of both subtypes are predicted to share a common org...
متن کاملThe yeast Na+/H+ exchanger Nhx1 is an N-linked glycoprotein. Topological implications.
Nhx1, the endosomal Na(+)/H(+) exchanger of Saccharomyces cerevisiae represents the founding member of a newly emerging subfamily of intracellular Na(+)/H(+) exchangers. These proteins share significantly greater sequence homology to one another than to members of the mammalian Na(+)/H(+) exchanger (NHE) family encoding plasma membrane Na(+)/H(+) exchangers. Members of both subtypes are predict...
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ژورنال
عنوان ژورنال: Microbiology
سال: 1999
ISSN: 1350-0872,1465-2080
DOI: 10.1099/00221287-145-11-3221